Really depends what you’re in it for.
To own the hot thing and flash it on InstaSnapKikTwitFace?
To have a piece of wrist jewellery that says “check me out, either I bought this a while ago before it was super cool making me a dude who was ahead of the curve, or I bought it at a massive premium which shows everyone that I have lots of disposable cash”?
To fit in with your friends, or pick up hot singles who find wrist jewellery attractive?
To own a particular design that you love?
To buy into the You Never Own A Patek Philippe buzz and brand?
To enjoy a sense of craftsmanship or other intrinsic value?
To buy high and hope to sell higher?
That’s a value judgment for you to make.
I would like to think I buy pieces which combine intrinsic value or craftsmanship - in some combination of the case, dial, movement, etc - with a design that speaks to me, without getting lost in branding, perceived prestige, or trendiness. My own value equation would put a high emphasis on the lovely design of the Nautilus but I’m not a huge fan of the movement, and have never been convinced by modern Patek at its ‘lower levels’ as an item of great rarity or superior craftsmanship, particularly vis-a-vis the company’s pricing (I know, I know - I will probably be called a heretic for saying this).
So for me, yes I would probably buy a Nautilus at retail, although I think the list price is already a bit high. If I really wanted one I would wait for my AD to come through - but I wouldn’t pay over retail for it.
Your mileage may vary...good luck and let us know what you decide!
Best
E.