Glad to see this thread resurrected! Two comments to add . . .
. . . to the discussion: first, your observation regarding the Ploprof's suitability for smaller wrists is on the money. It's a wide and thick design, which normally doesn't bode well for the wrist-challenged. The asymmetrical case and sloping bezel are the main reasons why it works for those of us with slender wrists. There are Panerais not nearly as large I couldn't wear. It's not so much the Ploprof doesn't seem large - it does, especially when viewed in a display case. It's that the randomness of its shape that mitigates its presence on the wrist.
Here's a pic of a titanium Ploprof on my wrist . . .
. . . taken four years ago. Large, yes, but not overwhelming. The sensation of lightness coupled with its appealing presence almost lead to an acquisition. It's that compelling a watch.
Second, when it comes to vintage Ploprofs, there's confusion over reversed crown positions. Even Omegamania was in on the act.
[photo credit: Antiquorum]
There were no 'left-handed' Ploprofs made to the best of my knowledge. Inverted examples are the result of uninformed watchmakers ordering date wheels for the cal 1002 movement. The Ploprof has a cal 1002 movement, but the case with crown at 9 mandates a specific wheel with a different part number.
And yes, these case-specific date wheels are difficult to source now.