Based on the run out list, my first guess would be for some larger case references (40mm) for the Calatrava, a new manual chronograph or either a 5170/1A or 5170/1P without any diamonds and a 5235R with new dial and hands.
The Nautilus line is more difficult to predict. PP keeps the remaining 5980s and drops the 5726s.
Is there a new Nautilus annual calendar, with different dial design, in the works?