Surprisingly, the 50mm case wasn't too large for my wrist. In fact, it actually felt pretty good on my wrist. I love wearing my 47mm Luminor and a slight increase in 3mm didn't seem to be overbearing for me.
If your local Panerai Boutique or AD ever has a PAM365 Equation of Time Tourbillon in stock, be sure to ask to try it on the wrist! It's not often you'll see one in the flesh.
Link to prior thread: panerai.watchprosite.com
Cheers,
Anthony